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Cortisol is produced in the adrenal cortex which also secretes the androgenic steroid testosterone and androgen precursors. These secretions are regulated by the hypothalamic-pituitary-adrenal HPA axis. Testosterone is additionally produced and secreted by the testes and ovaries which also secrete estradiol and other estrogens. These processes are controlled by the hypothalamic-pituitary-gonadal HPG axis. Additional amounts of estradiol may be contributed by the peripheral aromatization of testosterone.
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Within-person coupling of estradiol, testosterone, and cortisol in women athletes

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Within-person coupling of estradiol, testosterone, and cortisol in women athletes [PeerJ]

The incidence and expression of cardiovascular diseases differs between the sexes. This is not surprising, as cardiac physiology differs between men and women. Clinical and basic science investigations have shown important sex differences in cardiac structure and function. The pervasiveness of sex differences suggests that such differences must be fundamental, likely operating at a cellular level. Indeed, studies have shown that isolated ventricular myocytes from female animals have smaller and slower contractions and underlying calcium transients compared to males.
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Sex differences in mechanisms of cardiac excitation–contraction coupling

Over the past decades, the decline in Black marriages and the upsurge of never-married Blacks have stimulated much theoretical focus, but researchers conducted few studies on never-married heterosexual Black adults' coupling unions. Guided by an integrated framework of Africana womanism and symbolic interactionism, this qualitative hermeneutic phenomenological study used comprehensive individual interviews to explore the experiences of 26 never-married heterosexual Black men and women between the ages 25 and 35 about their attempts to cultivate and maintain intimate romantic relationships as well as their desire for marriage. Findings revealed mixed emotions from participants' lived experiences in developing and sustaining romantic relationships. Clinical implications highlighted the need to effectively attend to Black romantic relationships and experiences in their sociohistorical and sociocultural contexts.
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